Morphine is one of the go-to medicines of people experiencing severe or chronic pain. The opioid painkiller has long been the gold standard treatment for acute pain, but this might change from now on as a new study suggests an unfortunate irony: instead of providing pain relief, the medication could make chronic pain worse and slow down the recovery in some cases.
The study, published in the Proceedings of the National Academy of Sciences, offers a glimpse into the possible long-term consequences of opiates like morphine and oxycodone. Researchers at the University of Colorado Boulder used genetic and pharmacological interventions, including the novel Designer Receptor Exclusively Activated by Designer Drugs (DREADD) to demonstrate how a course of morphine after nerve injury doubles the duration of neuropathic pain in mouse models. They've found out that morphine activates spinal immune cells, amplifying pain rather than dulling it, even after the painkilling treatment has been stopped.
Rat models show that "the pain is effectively transitioned to a chronic state, making the pain itself both more severe and longer lasting.” The opioid activates inflammasome, a specific group of signaling proteins in microglia that sends pain signals up to the brain. Previous studies have shown that opioid painkillers make microglia, the immune cells of the brain, more sensitive to activation that is likely a factor that could explain opioid-induced hyperalgesia.
While the results show fundamental clinical implications for pain, researchers stress that they shouldn't be used as the basis for not giving opioids to people in pain. An awareness of the side effects of pain medications coupled with a deeper understanding of pain and the many non-drug alternatives available for pain management promotes a holistic approach to chronic pain. Stress management, diet, and exercise, and gentle manual medicine could go a long way in conquering pain and maintaining an active life without medications.
Dr. Melanie Novak, M.D., uses a multidisciplinary approach in the diagnosis and treatment of all types of pain. Her practice focuses on providing individualized treatment plans that help patients stay on top of their pain best and enjoy life. Read more about pain management here.
Image source: everydayhealth.com
The study, published in the Proceedings of the National Academy of Sciences, offers a glimpse into the possible long-term consequences of opiates like morphine and oxycodone. Researchers at the University of Colorado Boulder used genetic and pharmacological interventions, including the novel Designer Receptor Exclusively Activated by Designer Drugs (DREADD) to demonstrate how a course of morphine after nerve injury doubles the duration of neuropathic pain in mouse models. They've found out that morphine activates spinal immune cells, amplifying pain rather than dulling it, even after the painkilling treatment has been stopped.
Image source: publichealthwatch.wordpress.com
Rat models show that "the pain is effectively transitioned to a chronic state, making the pain itself both more severe and longer lasting.” The opioid activates inflammasome, a specific group of signaling proteins in microglia that sends pain signals up to the brain. Previous studies have shown that opioid painkillers make microglia, the immune cells of the brain, more sensitive to activation that is likely a factor that could explain opioid-induced hyperalgesia.
While the results show fundamental clinical implications for pain, researchers stress that they shouldn't be used as the basis for not giving opioids to people in pain. An awareness of the side effects of pain medications coupled with a deeper understanding of pain and the many non-drug alternatives available for pain management promotes a holistic approach to chronic pain. Stress management, diet, and exercise, and gentle manual medicine could go a long way in conquering pain and maintaining an active life without medications.
Dr. Melanie Novak, M.D., uses a multidisciplinary approach in the diagnosis and treatment of all types of pain. Her practice focuses on providing individualized treatment plans that help patients stay on top of their pain best and enjoy life. Read more about pain management here.
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